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CRISPR和精确基因编辑的三个神话

□ 时间:2019-2-4 □ 来源: 独立科学新闻


    God’s red pencil? CRISPR and the three myths of precise genome editing
    上帝的红铅笔?CRISPR和精确基因编辑的三个神话

For the benefit of those parts of the world where public acceptance of biotechnology is incomplete, a public relations blitz is at full tilt. It concerns an emerging set of methods for altering the DNA of living organisms. “Easy DNA Editing Will Remake the World. Buckle Up“; “We Have the Technology to Destroy All Zika Mosquitoes“; and “CRISPR: gene editing is just the beginning”. (CRISPR is short for CRISPR/cas9, which is short for Clustered Regularly-Interspaced Short Palindromic Repeats/CRISPR associated protein 9; Jinek et al., 2012. It is a combination of a guide RNA and a protein that can cut DNA.)

    为了(获取)世界上那些对生物技术接受程度尚不完整的地方的利益,一场公关宣传闪电战正全方位出动,它是关于一套正在出现的改变生物体DNA的方法。“简易DNA编辑将重塑世界。做好准备”,“我们拥有摧毁所有寨卡蚊子的技术”,还有“CRISPR:基因编辑才刚刚开始”。(CRISPR是CRISPR/cas9的简称,后者是“成簇规律间隔短回文重复序列/成簇规律间隔短回文重复序列关联蛋白9”的缩写;Jinek等,2012。它是一个引导RNA与一个可以切割DNA的蛋白质的组合。)

The hubris is alarming; but the more subtle element of the propaganda campaign is the biggest and most dangerous improbability of them all: that CRISPR and related technologies are “genome editing” (Fichtner et al., 2014). That is, they are capable of creating precise, accurate and specific alterations to DNA.
    这种夸张其辞固然令人

资讯作者: Jonathan Latham 源信息发布时间: 2016/5/3 编辑:金阳
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